Early Arterial Catheter Use in Mechanically Ventilated ICU Patients

Target trial–inspired RWE study using MIMIC data

Author

Ousmane Diallo, MPH-PhD

Project Overview

Objective Estimate the association between indwelling arterial catheter (IAC) use and 28-day mortality among mechanically ventilated adult ICU patients.

Data source MIMIC-III (PostgreSQL, AWS RDS)

Study design Retrospective observational cohort, target-trial–inspired.

Project Structure

📄 Protocol v2.0 (Active – MIMIC-III) → View protocol
📄 Protocol v1.0 (Archived – MIMIC-II) → View archived protocol
📊 Results & models → View Results

Why this project matters (RWE relevance)

Emulates a target trial under real EHR constraints
Explicit handling of immortal time bias
Clear separation of time zero vs exposure window
Reproducible SQL-first cohort construction

Ousmane Diallo, MPH-PhD – Biostatistician, Data Scientist & Epidemiologist based in Chicago, Illinois, USA. Specializing in SAS programming, CDISC standards, and real-world evidence for clinical research.